发明名称 |
Methods for producing polypeptides in fungal cells |
摘要 |
The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a mutant of a parent fungal cell under conditions conducive for the production of the polypeptide, wherein the mutant cell comprises a first nucleic acid sequence comprising a modification of one or more genes of a pacC pH signal transduction pathway or homologues thereof, and a second nucleic acid sequence encoding the polypeptide; and (b) isolating the polypeptide from the cultivation medium. |
申请公布号 |
AU2755300(A) |
申请公布日期 |
2000.08.25 |
申请号 |
AU20000027553 |
申请日期 |
2000.02.02 |
申请人 |
NOVO NORDISK BIOTECH, INC. |
发明人 |
DEBBIE S. YAVER |
分类号 |
C12N15/09;C07K14/37;C07K14/38;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/00;C12N9/02;C12N9/10;C12N9/14;C12N9/62;C12N9/88;C12N9/90;C12N15/31;C12N15/80;C12P21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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