| 摘要 |
The present invention is directed towards the diagnosis of malignant cancer by detection of the mts-1 MRNA or the <highlight><uline>mts-1</uline></highlight> protein, encoded by the <highlight><uline>mts-1</uline></highlight> gene. The present invention contemplates the use of recombinant mts-1 DNA and antibodie4 directed against the mts-1 protein to diagnose the metastatic potential of several types of tumor cells, including, for example, thyroid, epithelial, lung, liver and kidney tumor cells. The present invention is also directed to mammalian cell lines and tumors with high and low metastatic potential which have been developed to serve as tseful model systems for in vitro and in vivo anti-metastasis drug screening. |
