| 摘要 |
<p>The Applicants have discovered a novel antibody, more specifically a chimerized anti-human CD40 monoclonal antibody, which blocks the interaction between gp39 and CD40. The anti-CD40 antibodies of the present invention are effective in modulating humoral immune responses against T cell-dependent antigens, collagen induced arthritis, and skin transplantation, and are also useful for their anti-inflammatory properties.</p> |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
ARUFFO,ALEJANDRO A.;HOLLENBAUGH,DIANE;SIADAK,ANTHONY W.;BERRY,KAREN K.;HARRIS,LINDA J.;THORNE,BARBARA A.;BAJORATH,JURGEN;WU,HERREN;HUSE,WILLIAM D.;WATKINS,JEFFRY D. |
