发明名称 Neuroprotective substituted piperidine compounds with activity as NMDA NR2B subtype selective antagonists
摘要 The invention relates to a compound of the formula its R,R-, S,S-enantiomers and racemic mixtures thereof and to their pharmaceutically acceptable acid addition salts. The compound of formula I and its R,R- and S,S-enantiomers may be used as medicaments for the treatment of diseases, wherein the therapeutic indications include acute forms of neurodegeneration caused by stroke or brain trauma; chronic forms of neurodegeneration such as Alzheimer's disease, Parkinson's disease, Huntington's disease or ALS (amyotrophic lateral sclerosis); neurodegeneration associated with bacterial or viral infections, and, diseases such as schizophrenia, anxiety, depression and chronic/acute pain.
申请公布号 US2001047014(A1) 申请公布日期 2001.11.29
申请号 US20010811888 申请日期 2001.03.19
申请人 ALANINE ALEXANDER;BUETTELMANN BERND;NEIDHART MARIE-PAULE H.;JAESCHKE GEORG;PINARD EMMANUEL;WYLER RENE 发明人 ALANINE ALEXANDER;BUETTELMANN BERND;NEIDHART MARIE-PAULE H.;JAESCHKE GEORG;PINARD EMMANUEL;WYLER RENE
分类号 C07D211/50;A61K31/445;A61P21/04;A61P25/06;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P29/00;C07D211/48;(IPC1-7):C07D211/40 主分类号 C07D211/50
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