摘要 |
<p>This invention provides a compound of the following formula: <CHEM> or the pharmaceutically acceptable salts thereof wherein R<1> is H or C1-4 alkyl; R<2> is C(=L')R<3> or SO2R<4>; Y is a direct bond or C1-4 alkylene; L and L' are independently oxygen or sulfur; Q is selected from the following: C1-6 alkyl. halo-substituted C1-4 alkyl, optionally substituted C3-7 cycloalkyl, optionally substituted phenyl or naphthyl, optionally substituted 5 or 6-membered monocyclic aromatic group; R<3> is -OR<6>, -NR<7>R<8>, N(OR<1>)R<7> or a group of formula: <CHEM> Z is a direct bond, O, S or NR<5>; R<4> is C1-6 alkyl, halo-substituted C1-4 alkyl, optionally substituted phenyl or naphthyl; R<5> is C1-4 alkyl or halo-substituted C1-4 alkyl; R<6> is C1-4 alkyl, C3-7 cycloalkyl, C1-4 alkyl-C3-7 cycloalkyl, halo-substitutued C1-4 alkyl, optionally substituted C1-4 alkyl-phenyl or phenyl; R<7> and R<8> are each selected from the following: H, optionally substituted C1-6 alkyl, optionally substituted C3-7 cycloalkyl, optionally substituted C1-4 alkyl-C3-7 cycloalkyl, and optionally substituted C1-4 alkyl-phenyl or phenyl; X is each selected from halo, C1-4 alkyl. halo-substitutued C1-4 alkyl, OH, C1-4 alkoxy, halo-substitutued C1-4 alkoxy, C1-4 alkylthio, NO2, NH2, di-(C1-4 alkyl)amino and CN; n is 0, 1, 2 or 3; and r is 1, 2 or 3. This invention also provides a pharmaceutical composition useful for the treatment of a medical condition in which prostaglandins are implicated as pathogens.</p> |