DERIVATIVES OF MONOSACCHARIDES AS CELL ADHESION INHIBITORS.

摘要

THIS INVENTION RELATES GENERALLY TO COMPOUNDS AND PROCESSES FOR SYNTHESIZING DERIVATIVES OF 2-3-0-ISOPROPYLIDENE-ALPHA-L-XYLO-2-HEXULOFURANOSONIC ACID. THE COMPOUNDS OF THIS INVENTION ARE USEFUL, INTER-ALIA, FOR THE INHIBITION AND PREVENTION OF CELL ADHESION AND CELL ADHESION-MEDIATED PATHOLOGIES, INCLUDING INFLAMMATORY AND AUTOIMMUNE DISEASES, SUCH AS BRONCHIAL ASTHMA, RHEUMATOID ARTHRITIS, TYPE 1 DIABETES, MULTIPLE SCLEROSIS, ALLOGRAFT REJECTION AND PSORIASIS. THIS INVENTION ALSO RELATES TO PHARMACOLOGICAL COMPOSITIONS CONTAINING DERIVATIVES OF 2-3-0-ISOPROPYLIDENE-ALPHA-L-XYLO-2-HEXULOFURANOSONIC ACID AND THE METHODS OF TREATING SUCH PATHOLOGIES AS LISTED ABOVE.