14-Hydroxy dihydronormorphinone prepn. - from 1-halo-nor codeinone, by oxidn., catalytic redn. and hydrolysis

摘要

14-Hydroxydihydronormorphinone is prepd. (a) by oxdn. pref. using Na dichromate of a cpd. of formula (I): (where X is Cl or Br, Y is -CHO, -COOCH3 or -COOC2H5) to give cpd. of formula (II): (b) cpd. (II) is catalytically reduced to cpd. of formula (III): and (c) cpd. (III) is hydrolysed.