| 摘要 |
1440275 Respiratory stimulating composition RICHTER GEDEON VEGYESZETI GYAR RT 21 Dec 1973 [15 Jan 1973] 59324/ 73 Heading A5B A stable injectable solution comprises (i) an aminoketone derivative of formula: wherein R1 is hydrogen or C1-4 alkyl and R2 is alkylphenyl wherein the alkyl group contains 1 to 10 carbon atoms or R1 and R2 together represent a C3-5 alkylene group and X represents an anion or one equivalent of a polyvalent anion, (ii) a nonionic surface active agent, (iii) a polyhydric alcohol, (iv) an ammonium or amine salt of a strong acid and (v) an organic acid having a pKa value between 2 and 4. In the formula X may be chloride or sulphate. Compounds specified include (i) 1- piperidino - 3 - (4' - n - octylphenyl) - propan- 3-one hydrochloride, 1-piperidino-2-methyl-3- (4-methylphenyl)-propan-3-one hydrochloride and 1-piperidino-methyl-cyclohexane-2-one hydrochloride (ii) an oleic ester-alkylene oxide adduct, a castor oil-ethylene oxide adduct, sorbitan monolaurate-ethylene oxide adduct, (iii) propyleneglycol, glycerol, polyethylene glycol, (iv) ammonium chloride, piperidine hydrochloride, (v) ascorbic acid, maleic acid. The composition may also include a local anaesthetic, e.g. lindocaine hydrochloride. |
