发明名称 |
SEFUAROSUHORINNO SANSORUIENKAGOBUTSUNOSEIZO |
摘要 |
<p>In accordance with this invention, it has been found that the oxygen analog of 7-aminocephalosporanic acid and biologically active derivatives thereof can be formed from esters of 7-aminocephalosporanic acid. Esters of 7-oxocephalosporanic acid can be formed by diazotization of an ester of 7-aminocephalosporanic acid and contact of the diazo compound so formed with a hypohalous acid and a base in a water miscible organic solvent. Oxygen analogs of 7-aminocephalosporins isolated as esters are then formed by reducing the aforesaid ester to the corresponding 7 beta -hydroxy-cephalosporanate and then forming the desired analog by introduction of a side chain via hydroxyl group modification. Oxygen analogs of 7-aminocephalosporins are then formed by regeneration of the acid via protective group removal.</p> |
申请公布号 |
JPS5141382(A) |
申请公布日期 |
1976.04.07 |
申请号 |
JP19750093003 |
申请日期 |
1975.07.30 |
申请人 |
MASSACHUSETTS INST TECHNOLOGY |
发明人 |
JON SHII SHIIHAN;YAN SETSUKU RO |
分类号 |
C07D501/00 |
主分类号 |
C07D501/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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