| 发明名称 |
HYPROMELLOSE-GRAFT-CHITOSAN AND METHODS THEREOF FOR SUSTAINED DRUG DELIVERY |
| 摘要 |
Described herein is a drug delivery system, which is based on a novel polymer namely hypromellose-graft-chitosan (HC), useful to deliver a drug to a patient in sustained and controlled release fashion. HC is highly water soluble across the pH range from 1.2 to 10, and has a high pH buffering capacity to provide a pH-stable environment for drug delivery. In addition, the drug delivery system provided herein exhibited a drug loading efficiency of over 90% in all drugs tested, which is 1-2 fold higher than the efficiency attainable by conventional chitosan, and achieved a 2-3 fold longer duration of sustained drug release. |
| 申请公布号 |
US2016310440(A1) |
申请公布日期 |
2016.10.27 |
| 申请号 |
US201615130368 |
申请日期 |
2016.04.15 |
| 申请人 |
THE UNIVERSITY OF HONG KONG |
发明人 |
LAI Wing Fu;SHUM Ho Cheung |
| 分类号 |
A61K9/70;A61K31/5415;A61K31/58;A61K31/4164;A61L31/16;A61K47/36;A61K9/00;A61L26/00;A61L31/10;A61K31/65;A61K47/38 |
主分类号 |
A61K9/70 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A drug delivery system for controlled and sustained delivery of an effective amount of a drug to a subject, comprising:
a matrix comprising: (i) a hypromellose-graft-chitosan (HC); or (ii) a HC polyelectrolyte complex; and one or more drugs dispersed in the matrix. |
| 地址 |
Hong Kong HK |
