COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF CANCERS

摘要

The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one carboxylate or carbamate ligand.

主权项

1. A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: Y is independently selected from NH and CH2; X is independently selected from acylhydrazone, ester, amide or CH2; n and m are independently selected from 0, 1, 2, 3, 4, 5, and 6; R1 and R2 each is Cl, or R1 and R2 are joined to form an oxalate; R3 and R4 each is NH3, or R3 and R4 are joined together to form cyclohexane-1,2-diamine and R5 is alkyl or