| 摘要 |
Manufacture of chiral azetidinones of the general formula …<CHEM>… wherein R is an amino protecting group and M +/ &cir& is a cation, starting from L-ascorbic acid. Several alternatives lead, over a number of novel intermediates, to a novel intermediate of the formula …<CHEM>… wherein R and M +/ &cir& are as above and R<9>O- is a leaving group, which is treated with an alkali metal carbonate or bicarbonate, whereupon the compound of formula II is recovered from the reaction mixture. …<??>The compounds of formula II are useful for preparing the new sulfazecin related antibiotic compound of the formula …<CHEM>… …<??>This new antibiotic is similar in activity to the antibiotic azthreonam and useful in treating infectious diseases caused by gram negative microorganisms, particularly P. aeruginosa. |
