发明名称 RECOMBINANT LOW VIRULENCE BOVINE HERPESVIRUS-1 (BOHV-1) VACCINE VECTORS
摘要 The present disclosure teaches generally in the field of vaccination and disease control in cattle and bovine animals. A recombinant bovine herpesvirus 1 (BoHV-1) vaccine vector is provided for efficient control of one or more bovine pathogens such as those associated with bovine respiratory disease complex, such as bovine viral diarrhea virus (BVDV), and which ameliorates disease conditions caused thereby. Protocols for the management of confined or herded bovine animals are also enabled herein.
申请公布号 US2016339096(A1) 申请公布日期 2016.11.24
申请号 US201615169555 申请日期 2016.05.31
申请人 TH STATE OF QUEENSLAND ACTING THROUGH THE DEPARTMENT OF AGRICULTURE AND FISH ;MEAT & LIVESTOCK AUSTRALIA LIMTED 发明人 MAHONY Timothy John
分类号 A61K39/12;C12N7/00;C12N15/86;A61K39/102 主分类号 A61K39/12
代理机构 代理人
主权项 1. A vaccine against at least one antigen from a bovine pathogen, said vaccine comprising a bovine herpes virus-1 (BoHV-1) genome from a low virulence BoHV-1 having genetic material encoding the at least one antigen which is heterologous to BoHV-1 inserted between two converging BoHV-1 genes wherein the insertion does not substantially down-regulate expression of the BoHV-1 genes, wherein the genetic material encoding the at least one antigen is inserted between the polyadenylation signals of two converging genes at a functionally equivalent site in another BoHV-1 to a site selected from the group consisting of between 16600 to 16700, 22400 to 22500; 40,700 to 40,800; 58,000 to 59,000; 67,000 to 68,000; 74,000 to 76,000; 84,000 to 85,000; 90,000 to 91,000; and 96,000 to 97,000 of BoHV-1 reference sequence GenBank Accession No. AJ004801.
地址 BRISBANE AU