发明名称 Reduction of high dose aspirin toxicity by dietary vitamin A
摘要 The present invention is directed to a development for alleviating the adverse side-effects of taking non-steroid analgesics and anti-inflammatory agents such as aspirin, by also ingesting vitamin A (or B-carotene) formulations. It has been found that vitamin A ingestion has a salutary and therapeutic effect, in that the vitamin A decreases toxicity, including ulcerogenesis, due to ingestion of such agents, e.g. aspirin. Aspirin per se is a very effective medication with pronounced analgesic properties, including the temporary relief of minor aches and pains, and is widely used (in small amounts) with no ill effects. However, since aspirin is a mild anti-coagulant, it sometimes causes bleeding of stomach ulcers, or aggravates pre-existing conditions of that nature. Thus the concomitant administration of vitamin A per se to humans taking aspirin is very effective in decreasing toxicity and inhibiting ulcerogenesis and bleeding in the stomach. Also effective, but less so, is B-carotene, a vitamin A precursor, which when assimilated into the body yields vitamin A or a derivative thereof.
申请公布号 US4491574(A) 申请公布日期 1985.01.01
申请号 US19830471498 申请日期 1983.03.02
申请人 ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY, A DIVISION OF YESHIVA UNIVERSITY 发明人 SEIFTER, ELI;RETTURA, GIUSEPPE
分类号 (IPC1-7):A61K31/605;A61K31/615 主分类号 (IPC1-7):A61K31/605
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