| 发明名称 | Non-hemolytic LLO fusion proteins and methods of utilizing same | ||
| 摘要 | The present invention provides recombinant proteins or peptides comprising a mutated listeriolysin O (LLO) protein or fragment thereof, comprising a substitution or internal deletion of the cholesterol-binding domain or a portion thereof, fusion proteins or peptides comprising same, nucleotide molecules encoding same, and vaccine vectors comprising or encoding same. The present invention also provides methods of utilizing recombinant proteins, peptides, nucleotide molecules, and vaccine vectors of the present invention to induce an immune response to a peptide of interest. | ||
| 申请公布号 | US9499602(B2) | 申请公布日期 | 2016.11.22 |
| 申请号 | US201414163269 | 申请日期 | 2014.02.12 |
| 申请人 | ADVAXIS, INC.;THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 发明人 | Paterson Yvonne;MaCiag Paulo |
| 分类号 | C12N1/20;C12N15/63;C07K14/705;A61K39/00;A61K39/385;C07K14/195;C12N9/52;A61K39/02;C07K16/00 | 主分类号 | C12N1/20 |
| 代理机构 | Pearl Cohen Zedek Latzer Baratz LLP | 代理人 | Cohen Mark;Pearl Cohen Zedek Latzer Baratz LLP |
| 主权项 | 1. A recombinant Listeria expressing a recombinant protein, said recombinant protein comprising a listeriolysin 0 (LLO) protein comprising a mutation of amino acid residues on positions 2, 9 and 10 in the cholesterol-binding domain (CBD) of said LLO protein, and wherein said CBD is set forth in SEQ ID NO: 18. | ||
| 地址 | Princeton NJ US | ||