| 摘要 |
NEW MATERIAL:The compound of formula I [R<1> is halogen, group of formula II (R<3> is H or alkyl) or 1-pyrrolidyl; R<2> is thienyl, thiazolyl, pyridyl, pyrrolyl, furylalkyl, pyridylalkyl or morpholino; X is halogen)] or its salt. EXAMPLE:6,7-Difluoro-1-(2-thienyl)-1,4-dihydro-4-oxoquinoline--3-carbox ylic acid. USE:An antibacterial agent having remarkable antibacterial activity against Gram-negative bacteria and Gram-positive bacteria. Useful also as a remedy for urethral infection, intestinal infection, etc. PREPARATION:The compound of formula I can be produced by halogenating the compound of formula III (X<1> is X), reacting with the compound of formula IV [R<4> is COR<9> (R<9> is alkyl), etc.; R<5> is alkyl], removing R<4> group from the resultant compound of formula V, reacting successively with the compound of formula VI and the compound of formula R<2>.NH2 and cyclizing and hydrolyz ing the produced compound of formula VII. |
