| 发明名称 |
Itraconazole formulations |
| 摘要 |
Provided herein is a pharmaceutical injectable formulation of itraconazole (10 mg/g) where the formulation comprises a solubilizer, a nonionic surfactant/emulsifier, a co-surfactant and a stabilizer. Further provided is a pharmaceutical formulation of itraconazole, said formulation comprising a solubilizer in a concentration of from about 20% to about 75%, a nonionic surfactant/emulsifier in a concentration of from about 20% to about 50%, a co-surfactant in a concentration from about 10% to about 45% and a stabilizer in a concentration of from about 1% to about 15%. |
| 申请公布号 |
US9468638(B2) |
申请公布日期 |
2016.10.18 |
| 申请号 |
US201113200285 |
申请日期 |
2011.09.22 |
| 申请人 |
Texas Southern University |
发明人 |
Liang Dong;Wu Lei;Joseph Mathew Kizhakkekara;John Jyothy Anie |
| 分类号 |
A61K31/496;A61K9/00;A61K47/10;A61K47/26;A61K47/44 |
主分类号 |
A61K31/496 |
| 代理机构 |
|
代理人 |
Adler Benjamin Aaron |
| 主权项 |
1. A pharmaceutical formulation of itraconazole, said formulation suitable for intravenous administration and consisting of:
itraconazole; polyoxyl 35 castor oil; a non-ionic surfactant/emulsifier; a co-surfactant; and, a stabilizer, wherein said non-ionic surfactant/emulsifier is selected from the group consisting of polyoxyethylene sorbitan monooleate, Polysorbate 20, and Polyoxyl 8 stearate. |
| 地址 |
Houston TX US |
