| 摘要 |
N-substituted 3,4-dihydropyrimidine derivatives of the formula: <IMAGE> wherein X1, X2 and X3 are the same or different and are hydrogen, nitro, halogen, cyano, trifluoromethyl, methylthio or lower alkoxy; R1 is (C1-C13) straight or branched alkoxy, (C4-C12) straight or branched alkenyloxy, (C5-C8) straight or branched alkynyloxy, (C1-C4) straight or branched alkyl, (C3-C6) cycloalkyl, -O-(CH2)n-A wherein n is 1, 2 or 3, A is cyclopropyl, cyclobutyl, cyclopentyl, or (C1-C3) haloalkyl, -O-(CH2)m-O-B wherein m is 1, 2, 3 or 4, B is (C1-C3) alkyl, or -O-(CH2)l-D wherein l is an integer from zero to 8, D is phenyl or substituted phenyl; R2 is (C1-C12) straight or branched alkyl, (C4-C7) straight or branched alkenyl, -(CH2)p-E wherein p is 1, 2 or 4, E is cyclopropyl, cyclobutyl or cyclopentyl, <IMAGE> wherein q is 2, 3 or 4, G and J are the same or different and are phenyl, methyl, ethyl, isopropyl, benzyl, phenethyl, methoxycarbonyl or ethoxycarbonyl, or -(CH2)r-O-L wherein r is 1 or 2, L is methyl, ethyl or phenyl, with the proviso that wherein R1 is methoxy or ethoxy, R2 is neither methyl nor ethyl, and pharmaceutically acceptable acid addition salts thereof are useful as agents for treating disorders of the cardiovascular system, for example, hypotensive agents, agents for ameriolation of brain circulation and anti-angina pectoris agents. Processes for producing the above compounds economically and effectively are also disclosed.
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