发明名称 |
Pharmaceutical composition for preventing and treating chronic obstructive pulmonary diseases, containing <i>Phyllostachys nigra Munro </i>var. <i>henosis </i>stapf extract as active ingredient |
摘要 |
The present invention relates to a method for treating chronic obstructive pulmonary disease (COPD) comprising the step of administering the extract of Phyllostachys nigra Munro var. henosis Stapf as an active ingredient. Particularly, the extract of Phyllostachys nigra Munro var. henosis Stapf of the present invention can reduce the numbers of macrophages and neutrophils increased in bronchoalveolar lavage fluid (BALF) and is effective in preventing weight loss caused by chronic obstructive pulmonary disease and is effective in down-regulating significantly IL-6, TNF-α, IL-1β, MCP-1, and MMP-12, which are rapidly increased in bronchoalveolar lavage fluid, intrapulmonary tissue, and serum according to the development of chronic obstructive pulmonary disease. In addition, the extract of Phyllostachys nigra Munro var. henosis Stapf of the present invention has the effect of blocking the activation of NF-κB signal in intrapulmonary tissue and significantly reduces inflammatory cells in the tissues around alveoli as well as significantly reduces the size of the enlarged alveola. Therefore, the extract of Phyllostachys nigra Munro var. henosis Stapf of the present invention can be effectively used as an active ingredient of medicines and health food for the prevention and treatment of chronic obstructive pulmonary disease. |
申请公布号 |
US9511108(B2) |
申请公布日期 |
2016.12.06 |
申请号 |
US201414491785 |
申请日期 |
2014.09.19 |
申请人 |
UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY |
发明人 |
Kim Jinju;Ko Eunjung;Lee Eui Jeong |
分类号 |
A61K36/899;A61K36/804;A61K36/074 |
主分类号 |
A61K36/899 |
代理机构 |
Klarquist Sparkman, LLP |
代理人 |
Klarquist Sparkman, LLP |
主权项 |
1. A method for treating a subject with emphysema, comprising administering an effective amount of an extract of Phyllostachys nigra Munro var. henosis Stapf to a subject in need thereof, thereby treating the emphysema. |
地址 |
Yongin-Si KR |