PROCESS FOR THE PREPARATION OF THE L-ARGININE SALT OF PERINDOPRIL

摘要

Preparing perindopril L-arginine salt (I) comprises reacting perindopril and L-arginine in a solvent system comprising a binary mixture of acetonitrile and dimethyl sulfoxide, a binary mixture of ethyl acetate and dimethyl sulfoxide, and a ternary mixture of acetonitrile, dimethyl sulfoxide and toluene, at a temperature of 10-100[deg] C; and isolating (I) by filtration. ACTIVITY : Cardiovascular-Gen.; Hypotensive; Cardiant; Vasotropic. MECHANISM OF ACTION : Angiotensin I converting enzyme inhibitor.