| 摘要 |
A method of obtaining naproxen from racemic 6-methoxy-α-methyl-2-naphthylacetic acid consisting in creating diastereoisomeric esters, dismembering them by means of crystallization into active enantiomers, and then hydrolysis, characterized in that for the purpose of creating the diastereoisomeric esters of the 6-methoxy-α-methyl-2-naphthylacetic acid the halide of peracetyl derivative of α-D-glucopyranose is used, whereas salts of the 6-methoxy-α-methyl-2-naphthylacetic acid are subject to the action of a halide, preferably bromide of peracetyl derivative of the α-D-glucopyranose, in the presence of inorganic bases or tertiary alcohols, in the environment of non-polar inorganic solvents or aprotic polar solvents, or in a diphase liquid-liquid system in the presence of phase transfer catalysts.<IMAGE>
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