METHOD OF PACKAGING FREEZE DRIED VACCINES IN SYRINGES AND PLUG FOR IMPLEMENTING THE METHOD

摘要

In a method of packaging freeze dried vaccine in a bypass syringe sterilized syringes are disposed in rows in an aseptic dispensing machine. Doses of a solution or suspension to be freeze dried are introduced into the syringes. A temporary plug is inserted in the same machine into the mouth of the syringe body in a position allowing communication between the interior of the syringe body and the exterior. The syringes are introduced into a freeze drying machine. The vaccine is freeze dried. At the end of the freeze drying cycle the temporary plug is depressed in a controlled atmosphere in the freeze drying machine into a hermetic sealing position. The syringes are transferred into an aseptic dispensing machine. The temporary plug is removed. An intermediate piston-plug is fitted. The dose of solvent is introduced and an end piston-plug is fitted.