| 摘要 |
Spoj formule (I) gdjeR1 jeH, (C1-C6)alkil, R', NH-(C1-C6)alkil, NHR', iliN[(Cl-C6)alkil]2;R2 je vodik, halogen ili (C1-C6)alkil; R3 jeH, halogen, (C1-C6)alkil, (C1-C6)alkilen-R', OH, O-R''NH2,NHR'', NR''R'' iliNH-C(O)-R'', R4 jeH, halogen, hidroksi, CN, (C1-C6)alkil, R', (C1-C6)alkilen-R'; R5 jeH, halogen, CN, NO2, (C1-C6)alkil, (C2-C6)alkenil, R' (C1-C6)alkilen-(C6-C10)aril, (C2-C6)alkenilen-(C6-C10)aril, (C1-C6)alkilen-(C5-C10)heterociklil, CH(OH)-(C1-C8)alkil, NH2,NH-R', NH-SO2H, NH-SO2-(C1-C6)alkil, NH-SO2-R', NH-C(O)-(C1-C6)alkil, NH-C(O)-R', C(O)N[(C1-C6)alkil]2,C(O)OH, iliC(O)O-(C1-C6)alkil; R6 jeH, R', (C1-C8)alkil, (C1-C6)alkil-R', (C1-C6)alkilen-O-(C1-C6)alkil, (C1-C6)alkilen-O-R', (C1-C6)alkilen-CH[R']2, (C1-C6)alkilen-C(O)-R', (C1-C6)alkilen-C(O)NH2, (C1-C6)alkilen-C(O)N-R', ili (C1-C5)alkilen-C(O)N[R']2;R7 jeH, halogen, CN, NO2, (C1-C6)alkil, (C2-C6)alkenR' (C2-C6)alkenilen-(C6-C10)aril, (C1-C6)alkilen-R', CH(OH)-(C1-C6)alkil, NH2,NH-R', NH-SO2H, NH-SO2-(C1-C6)alkil, NH-SO2-R', SO2-NH2,SO2-NHR', NH-C(O)-(C1-C6)alkil, NH-C(O)-R', C(O)N[(C1-C6)alkil]2,C(O)OH, iliC(O)O-(C1-C6)alkil; R8 je H, halogen ili (C1-C6)alkil; n je 1, 2, 3 ili 4; iL je O ili O-(C1-C6)alkilen; gdjeR' je (C3-C8)cikloalkil, (C5-C10)heterociklil, (C6-C10)aril; iR'' je (C3-C8)cikloalkil, (C5-C10)heterociklil, (C6-C10)aril, (C1-C6)alkil, (C1-C6)alkilen-R', (C1-C6)alkilen-O-(C1-C6)alkil, (C1-C6)alkilen-O-R', ili (C1-C6)alkilen-NRxRy; igdje Rx i Ry su međusobno neovisno (C1-C6)alkil, (C5-C10)heterociklil, (C6-C10)aril, (C1-C4)alkilen-(C5-C10)heterociklil, (C1-C4)alkilen-(C6-C10)aril, (C1-C4)alkilen-NH(C1-C6)alkil, (C1-C4)alkilen-N[(C1-C6)alkil]2, (C1-C4)alkilen-N[(C6-C10)alkil]2, ili (C1-C4)alkilen-N[(C5-C10)heterociklil]2; igdje u ostacima R4, R5, R7 i R8 jedan alkilni ili alkilenski atom vodika može izborno biti supstituiran s OH, F, OCH3, COOH, COOCH3, NH2, NHCH3, N(CH3)2, CONH2, CONHCH3 ili CON(CH3)2;i njegove farmaceutski prihvatljive soli. Patent sadrži još 35 patentnih zahtjeva. |
