THERAPEUTIC AGENTS

摘要

The invention provides compounds of formula (I): wherein R<2> is phenyl optionally substituted by one or more substituents each independently selected from nitro, halo, C1-C4 alkyl, C1-C4 alkoxy, fluoro-(C1-C4)alkoxy, aryl-(C1-C4 alkoxy), C1-C4 alkylthio, C1-C4 alkylsulphonyl, hydroxy, trifluoromethyl and cyano; R<1> is C1-C6 alkyl or aryl-(C1-C4)alkyl; Y is an alkylene group of from 2 to 8 carbon atoms which may be straight or branched-chain having at least 2 carbon atoms in the chain linking X to the oxygen atom; X is 1-imidazolyl optionally substituted with from 1 to 3 substituents which may be C1-C4 alkyl groups or halogen atoms, or wherein the 3 and 4 positions may be linked by -(CH2)p- where p is 3 or 4; or 1- or 2-benzimidazolyl optionally substituted with one or more substituents each selected from C1-C4 alkyl, C1-C4 alkoxy, halo, CF3 and CN; and Z completes a 5 or 6 membered carbocyclic or heterocyclic ring having a carbonyl group attached to the 5-position of the dihydropyridine ring; wherein "aryl" means phenyl optionally substituted by one or more substituents each independently selected from halo, trifluoromethyl, C1-C4 alkyl, hydroxy, C1-C4 alkoxy, (C1-C4 alkoxy)carbonyl, sulphamoyl and cyano.