发明名称 |
Transdermal flux enhancing compositions |
摘要 |
A transdermal flux enhancing pharmaceutical composition for transdermal administration to a human or lower animal subject comprising a safe and effective amount of pharmacologically active compound or a prodrug thereof, an aqueous solvent system comprising from about 15 to 75% by volume of one or more water miscible solvents, and a penetration enhancer selected from certain 1-alkylazacycloheptan-2-ones and cis-olefin compounds of the formula CH3(CH2)xCH=CH(CH2)yR3 where R3 is CH2OH, CH2NH2 or COR4 and R4 is OH or (C1-C4)alkoxy, x and y are each an integer from 3 to 13 and the sum of x and y is from 10 to 16; methods for their use in treating various illnesses in a human or lower animal by transdermal administration of said composition.
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申请公布号 |
US5196410(A) |
申请公布日期 |
1993.03.23 |
申请号 |
US19910759705 |
申请日期 |
1991.09.11 |
申请人 |
PFIZER INC. |
发明人 |
FRANCOEUR, MICHAEL L.;POTTS, RUSSELL O. |
分类号 |
A61K47/10;A61K47/12;A61K47/18;A61K47/22 |
主分类号 |
A61K47/10 |
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