PREVENTIVE OR REMEDY FOR ISCHEMIA, REPERFUSION-INDUCED TISSUE DISORDER AND ARRHYTHMIA AS WELL AS PULMONARY DISORDER CAUSED BY ACTIVATED OXYGEN FREE RADICAL.

摘要

A preventive or remedy for free radical-induced tissue disorder, which contains a q-L-glutamyl-L-cysteine ester derivative represented by general formula (I) or its dimer in oxidized form as an active ingredient wherein R represents C<5> to C<5><4> linear, branched or cyclic hydrocarbyl or aromatic-substituted C<5> to C psi linear or branched hydrocarbyl. The above compound has tissue glutathione improving and biochemical glutathione replacing and reperfusion-induced tissue disorder of the heart, liver, etc., arrhythmia, and pulmonary disorder caused by activated oxygen.