HUMAN IL-15-SECRETING IMMUNODEFICIENT MOUSE

摘要

The present invention addresses the problem of providing a mouse by using which the function of human NK cells can be examined. An NOD-scid,IL-2rγnull-hIL-15 Tg mouse that is prepared by inserting DNA comprising a base sequence represented by SEQ ID NO:1, said base sequence being a gene region containing DNA wherein a cDNA sequence encoding interleukin 15 (IL-15) is operably linked to a cDNA sequence encoding the signal peptide of human interleukin 2 (IL-2), into cDNA of an immunodeficient mouse. From this mouse, hCD56+ cells can be detected at a concentration sufficient for studying in vivo mature human NK cells at least for 6 months after the transplantation.