| 摘要 |
Leukotriene B4 derivs. of formula (I) and (if R5 = H) their salts with physiologically acceptable bases and their cyclodextrin calthrates are new (where R1 = CH2OH, Me, CF3, COOR5, CONR6R7 or R1 and R2 together form carbonyl, R2 and R3 = each H or a 1-15C organic acid gp., R4 = H, 1-10C alkyl (opt. mono or polysubstd. with Cl or Br), 3-10C cycloalkyl, 6-10C aryl (opt. mono- or poly-substd. with Cl, Br, Ph, 1-4C alkyl, 1-4C alkoxy, fluoromethyl, chloromethyl trifluoromethyl, COOH or OH or a 5-6 membered aromatic heterocyclic ring contg. at least 1 heteroatom, R5 = H, 1-10C alkyl, 3-10C cycloalkyl, 6-10C aryl (opt. substd. with 1-3 gps. chosen from Cl, Br, Ph, 1-4C alkyl, 1-4C alkoxy, fluoromethyl, chloromethyl, trifluoromethyl, COOH or OH), CH2CO(6-10C) aryl or a 5-6 membered ring contg. at least 1 heteroatom, A = trans-trans-CH=CH-CH=CH-, -CH2CH2CH=CH- or tetramethylene, B = 1-10C opt. branched alkylene opt. substd. with F or (II), D = a direct bond, O, S, -C=C-, -CH=CR8- or together with B also forms a direct bond, R6 and R7 = each H or 1-4C alkyl or R7 = H and R6 = 1-10C alkanoyl or 1-10C alkane sulphonyl, R8 = H, 1-5C alkyl, Cl or Br, m = 1-4, n = 3-5).
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