发明名称 |
Formulations comprising olin 10-G to prevent particle aggregation and increase stability |
摘要 |
This invention discloses a composition comprised of nanoparticles having p-isononylphenoxypoly (glycidol) as a surface modifier adsorbed on the surface thereof. In preferred embodiments, the p-isononylphenoxypoly (glycidol) provides resistance to particle aggregation during heat sterilization. In another preferred embodiment, those nanoparticles also comprise a stability enhancing compound. A preferred stability enhancing compound is albumin. This invention further discloses a method of making nanoparticles having p-isononylphenoxypoly(glycidol) as a surface modifier adsorbed on the surface, comprised of contacting said nanoparticles with p-isononylphenoxypoly(glycidol) for a time and under conditions sufficient to form a p-isononylphenoxypoly(glycidol) surface modified nanoparticle. In a preferred embodiment, the p-isononylphenoxypoly (glycidol) surface modified nanoparticle is further contacted with a stability enhancing compound for a time and under conditions sufficient to form a p-isononylphenoxypoly(glycidol) surface modified nanoparticle with a stability enhancing compound associated therewith.
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申请公布号 |
US5340564(A) |
申请公布日期 |
1994.08.23 |
申请号 |
US19920988564 |
申请日期 |
1992.12.10 |
申请人 |
STERLING WINTHROP INC. |
发明人 |
ILLIG, KATHLEEN J.;SARPOTDAR, PRAMOD |
分类号 |
A61K9/14;A61K49/04;(IPC1-7):A61K9/14;A61K31/075 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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