Liponucleotide compounds.

摘要

The present invention relates to new liponucleotide analog compounds having useful antiviral activity, represented by general formula (I) : <CHEM> wherein R<1> is a saturated or unsaturated alkyl having 6-22 C atoms ; R<2> is a saturated or unsaturated alkyl having 12 - 20 C atoms ; R<3> and R<4> are each hydrogen or hydroxy ; and B is one of the nucleoside bases of formula (a): <CHEM> wherein R<5> is a hydrogen, halogen, hydroxy, amino, mercapto, or C1 - C4 alkyl amino ; R<6> is a hydrogen, halogen or amino ; W is a nitrogen or C - R<8> where R<8> is hydrogen, halogen, amino or C1 - C4 alkyl, and pharmaceutically acceptable salts thereof.