| 发明名称 |
SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE |
| 摘要 |
The present invention provides a compound having the structure:;whereinR1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl,
wherein two or more of R1, R2, R3r R4, or R5 are other than H;R6 is H, OH, or halogen; andB is a substituted or unsubstituted heterobicycle,wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than;;or a pharmaceutically acceptable salt thereof. |
| 申请公布号 |
US2016368925(A1) |
申请公布日期 |
2016.12.22 |
| 申请号 |
US201615254966 |
申请日期 |
2016.09.01 |
| 申请人 |
Petrukhin Konstantin;Cioffi Christopher;Johnson Graham;Allikmets Rando;Freeman Emily;Chen Ping;Conlon Michael;Zhu Lei |
发明人 |
Petrukhin Konstantin;Cioffi Christopher;Johnson Graham;Allikmets Rando;Freeman Emily;Chen Ping;Conlon Michael;Zhu Lei |
| 分类号 |
C07D487/04;C07D471/04 |
主分类号 |
C07D487/04 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl,
wherein two or more of R1, R2, R3, R4, or R5 are other than H; R6 is H, OH, or halogen; and B is a substituted or unsubstituted heterobicycle, wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than or a pharmaceutically acceptable salt thereof. |
| 地址 |
New Windsor NY US |
