INJECTABLE EMULSIONS CONTAINING ANTIFUNGAL TRIAZOLE DERIVATIVES

摘要

An injectable oil-in-water emulsion composition comprises an antifungal triazole compound of formula (I) wherein Ar represents a substituted phenyl group; R<1> and R<2> represent, independently, a hydrogen atom or a lower alkyl group, or R<1> and R<2> may together form a lower alkylene group; R<4> represents a hydrogen atom or an acyl group; and A represents an optionally substituted cyclic amide group bonded through a nitrogen atom, or a salt thereof. The solubility of the triazole compound having poor water-solubility and fat-solubility can remarkably be increased by dispersing in water with use of an oil component (e.g. a triglyceride of fatty acids) and an emulsifier (e.g. a phospho-lipid).