5-VINYL- AND 5-ETHYNYL-QUINOLONE- AND NAPHTYRIDONE CARBOXYLIC ACIDS, METHOD OF OBTAINING THEM AS WELL AS ANTIBACTERIAL AGENTS AND FODDER ADDITIVES CONTAINING SUCH ACIDS

摘要

Quinolone and naphthyridone derivs. of formula (I), and their hydrates, acid addn. salts, and alkali-, alkaline earth, silver and guanidinium salts, are new. R1 = 1-4C alkyl (opt. substd. by OH, halo or 1-3C alkoxy), 3-6C cycloalkyl (opt. substd. by halo or 1-3C alkyl), 2-4C alkenyl, 1-3C alkoxy, amino, 1-3C monoalkylamino, 2-6C dialkylamino, or phenyl (opt. substd. by 1-3 halo); R2 = H, 1-4C alkyl or (5-methyl-2-oxo-1,3-dioxol-4-yl)-methyl; X = CH, C-halo, COMe, COCHF2, CMe or N; Z = CR4=CHR3 or C IDENTICAL CR5; R3 = H, 1-3C alkyl, 1-3C alkoxy, or 1-3C alkoxy-methyl; R4 = H or halo; R5 = H, 1-6C alkyl (opt. substd. by 1-3 halo or OH), 2-3C alkenyl, 1-3C alkoxy, 1-3C alkoxy-methyl, halo or SiMe3; R6 = H, 1-4C alkyl (opt. substd. by OH or OMe), cyclopropyl, 1-4C oxoalkyl, or 1-3C acyl; Y = NR'R"; NR'R" = pyrrolyl, imidazolyl or a specified satd. or mono-unsatd. mono-or bicyclic ring, (opt. contg. O or a second N, opt. substd.)