发明名称 |
ANTI-PD-L1 MONOCLONAL ANTIBODIES AND FRAGMENTS THEREOF |
摘要 |
The present invention is based, in part, on the discovery of monoclonal antibodies that specifically bind to the cytoplasmic domain of PD-L1 antibodies useful for diagnostic, prognostic, and therapeutic applications, as well as immunoglobulins polypeptides, and nucleic acids thereof. |
申请公布号 |
US2016272712(A1) |
申请公布日期 |
2016.09.22 |
申请号 |
US201415029369 |
申请日期 |
2014.10.24 |
申请人 |
DANA-FARBER CANCER INSTITUTE INC. |
发明人 |
Freeman Gordon J.;Sharpe Arlene H. |
分类号 |
C07K16/28;G01N33/577;G01N33/574;C07K16/30 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
1. A monoclonal antibody, or antigen-binding fragment thereof, wherein the monoclonal antibody comprises:
a) a heavy chain sequence with at least about 95% identity to a heavy chain sequence selected from the group consisting of the sequences listed in Table 1 or b) a light chain sequence with at least about 95% identity to a light chain sequence selected from the group consisting of the sequences listed in Table 1. |
地址 |
Boston MA US |