发明名称 |
Behandling av atherosklerose og andre kardiovaskulære og inflammatoriske sykdommer |
摘要 |
A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene. |
申请公布号 |
NO964742(A) |
申请公布日期 |
1996.11.08 |
申请号 |
NO19960004742 |
申请日期 |
1996.11.08 |
申请人 |
EMORY UNIVERSITY |
发明人 |
MEDFORD, RUSSEL M.;WAYNE, ALEXANDER R.;PARTHASARATHY, SAMPATH;KAHN, BOBBY V.;OFFERMANN, MARGARET K. |
分类号 |
G01N33/50;A61K31/10;A61K31/105;A61K31/145;A61K31/185;A61K31/198;A61K31/26;A61K31/27;A61K31/28;A61K31/325;A61K31/365;A61K31/40;A61K31/455;A61K31/55;A61K38/00;A61K45/00;A61K45/06;A61K49/00;A61P9/00;A61P9/08;A61P9/10;A61P11/00;A61P17/00;A61P29/00;A61P35/00;A61P43/00;C07C333/04;C07C333/08;C07C333/16;C07D295/21;G01N33/15;G01N33/68;G01N33/92;(IPC1-7):A61K31/40;A61K31/21 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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