TRANSCRANIAL BURST ELECTROSTIMULATION APPARATUS AND ITS APPLICATIONS

摘要

The invention provides transcranial electrostimulation by combining transcranial direct current stimulation (tDCS) and theta burst stimulation (TBS) to achieve an unexpected therapeutic effect in various brain or neural diseases. Accordingly, the invention provides a mode of direct current with biphasic square wave pulses in the treatment of brain or neural diseases. Also provided are methods of employing the transcranial electrostimulation of the invention and applications of the transcranial electrostimulation of the invention.

主权项

1. A transcranial electrostimulator, comprising:
a first current source providing direct current stimulation (tDCS), and a second current source providing a burst stimulation (TBS); wherein the tDCS is delivered with an adjustable direct current in a range of about 0 to +/− about 5 mA and the TBS is delivered with an alternating current with amplitude ranging from 0 to +/−5 mA and multiple bursts each having 2 to 5 pulses, each pulse having a pulse width of about 0.1 to about 3 ms and a gap of about 5 ms to 30 ms and repeating every 150 ms to 500 ms, wherein the bursts are continuous to provide continuous TBS (cTBS) or intermittent to provide intermittent TBS (iTBS).