发明名称 |
treatment for toxoplasmoisis with a composition containing a hydroxynaphthoquinone and a spiropiperidyl derivative of rifamycin S. |
摘要 |
A method of reducing the severity of toxoplasmosis resulting from infection of a patient with Toxoplasma gondii by administering to a patient in need of such treatment, either after infection or before exposure to infection, a therapeutically effective amount of a compound that is a spiropiperidyl derivative of rifamycin S, wherein the derivative comprises an imidazole ring that includes carbons at positions 3 and 4 of the rifamycin ring, the carbon at position 2 of the imidazole ring also being a ring carbon at position 4 of a piperidine ting system, thereby forming a spiropiperidyl ring system, the spiropiperidyl ring system optionally comprising a lower hydrocarbon substituent on the nitrogen of the piperidine.
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申请公布号 |
US5641769(A) |
申请公布日期 |
1997.06.24 |
申请号 |
US19950481689 |
申请日期 |
1995.06.07 |
申请人 |
PALO ALTO MEDICAL FOUNDATION |
发明人 |
REMINGTON, JACK S.;ARAUJO, FAUSTO G. |
分类号 |
C07D498/18;A61K31/395;A61K31/435;A61K31/4353;A61K31/438;A61K31/445;A61P33/02;A61P33/10;(IPC1-7):A61K31/33;A61K31/12 |
主分类号 |
C07D498/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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