发明名称 |
Process for microencapsulating cells |
摘要 |
Oxalate-degrading enzymes and bacteria were encapsulated for both enteric and intraperitoneal administration. We have shown that via alginate microencapsulation of Oxalobacter formigenes, enzymatic activity was retained for several months. A new process was developed which strengthened the alginate microcapsules and their tolerance to citrate treatment. Much smaller (30-50 mu m) alginate microcapsules were made for injection as means of implantation. For oral administration, multi-encapsulated microspheres of cellulose acetate phthalate in poly-2-vinylpyridine (pKa=3.5) were prepared to protect the enzymes from gastric juices.
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申请公布号 |
US5648099(A) |
申请公布日期 |
1997.07.15 |
申请号 |
US19940192212 |
申请日期 |
1994.02.03 |
申请人 |
UNIVERSITY OF FLORIDA |
发明人 |
BATICH, CHRIS;VAGHEFI, FARID |
分类号 |
A61K9/16;A61K9/50;A61K9/52;A61K35/12;A61K35/74;C12N11/04;(IPC1-7):A61K9/58;A61K9/62;B01J13/12 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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