PEPTIDE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION, METHOD OF INHIBITION OF TACHYKININ EFFECT

摘要

FIELD: chemistry of peptides. SUBSTANCE: products: derivatives of peptides of the formula (I): where R1 is hydrogen, (lower)-alkyl; R2 is (lower)-alkyl, halogen; R3 is hydrogen, (lower)-alkyl, halogen; R4 is (lower)- -alkyl; R5 is aryl, (lower)-alkyl; R6 is NH2 or optionally substituted hydroxyl-group, or their pharmaceutically acceptable salts. Compounds of the formula (I) are synthesized by interaction of compound (II): or its amino-group reactive derivative and compound (III): , or its amino-group reactive derivative. Invention relates to also pharmaceutical composition containing an effective amount of peptide derivative of the formula (I) as an active component or its pharmaceutically acceptable salt, method of inhibition of tachykinin effect by effect on tachykinin receptors - derivative of peptide of the formula (I) at effective amount. The synthesized compounds can be used for treatment of patients with respiratory diseases (asthma, bronchitis, rhinitis and others), ophthalmic diseases, skin diseases (contact dermatitis, diffuse neurodermitis, nettle rash), inflammatory diseases (rheumatic arthritis, osteoarthritis), pains (migraine, headache, tooth, cancer, back pains and others) in humans and animals. Synthesized compounds show antagonism with respect to tachykinin. EFFECT: improved method of synthesis, enhanced effectiveness of compounds synthesized. 6 cl, 4 dwg, 1 tbl, 28 ex