INCLUSION COMPLEXES OF N-ETHOXYCARBONYL-3-MORPHOLINO- -SYDNONIMINE, METHOD OF PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

摘要

Inclusion complexes of N-ethoxycarbonyl-3-morpholino- sydnonimine or its salts formed with a cyclodextrin derivative are suitable for the prevention and treating angina pectoris and ischemic diseases. The inclusion complex of N-ethoxycarbonyl-3- -morpholino-sydnonimine or its salt formed with cyclodextrin derivative is prepared by reacting the N-ethoxycarbonyl-3- -morpholino-sydnonimine or its salt and the cyclodextrin derivative in a solvent medium, and if desired recovering the complex from the solution by dehydratation; or high energy milling of the N-ethoxycarbonyl-3-morpholino-sydnonimine or its salt and the cyclodextrin derivative.