| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject new compound consisting of a specific silicic compound and useful as an adsorbent for amino acids, peptides, proteins, etc. SOLUTION: This compound is a compound having a partial structure of formula I (R1 to R4 are each O-Si, a group OR5 (R5 is H or a 1-4C alkyl) or the like), and is obtained by condensation reaction between a compound of formula II [R1' to R4' are each OH, a halogen, group of OR5' (R5' is H or a 1-4C alkyl) or the like] and a compound of formula III [R6 to R9 are each OH, a halogen, group of O-R10 (R10 is a 1-4C alkyl) or the like] in the weight ratio of pref. (40:60) to (70:30); wherein the above reaction is carried out pref. as follows: a dealcoholization reaction is made in the presence of an acid catalyst and then dehydration condensation reaction is made in the presence of a basic catalyst. An absorbent consisting of this compound can be used as a support for column chromatography intended for separation and can also be used for eliminating antigen proteins including allergens.
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