Compositions of anti-4-1BB antibody effective for immunomodulation and treatment of T-cell autoimmune disease

摘要

Disclosed is the use of anti-4-1BB antibody for suppressing a primary or secondary humoral response to a T-cell dependent antigen in a host. Also disclosed is a composition that contains the anti-4-1BB antibody wherein the antibody inhibits an antibody response to sheep red blood cells in vivo and can inhibit ligand binding to 4-1BB in vitro. This composition can be used to enhance lymphocytic killing of tumour cells and has been shown to be effective in treating a host with T cell autoimmune disease.