| 发明名称 | Opsin polypeptides and methods of use thereof | ||
| 摘要 | The present disclosure provides opsins, including variant opsins with increased activity and/or increased trafficking to the plasma membrane. The opsins are useful in therapeutic and screening applications, which are also provided. | ||
| 申请公布号 | US9505817(B2) | 申请公布日期 | 2016.11.29 |
| 申请号 | US201615097925 | 申请日期 | 2016.04.13 |
| 申请人 | The Board of Trustees of the Leland Stanford Junior University | 发明人 | Deisseroth Karl;Zhang Feng;Gradinaru Viviana |
| 分类号 | C07K14/47;C12N13/00 | 主分类号 | C07K14/47 |
| 代理机构 | Bozicevic, Field & Francis LLP | 代理人 | Bozicevic, Field & Francis LLP ;Borden Paula A. |
| 主权项 | 1. An isolated fusion polypeptide comprising: a) an opsin polypeptide comprising an amino acid sequence having at least 98% amino acid sequence identity to the amino acid sequence set forth in SEQ ID NO:31; b) an endoplasmic reticulum (ER) export signal; and c) a membrane trafficking signal. | ||
| 地址 | Stanford CA US | ||