METHYLIDENE PIPERIDINYL OXAZOLIDINONE DERIVATIVES AND PREPARATION METHOD THEREOF

摘要

PURPOSE: Methylidene piperidinyl oxazolidinone derivatives and a preparation method thereof are provided, which compounds have improved antimicrobial activity, so that they can be useful for treatment of infection of pathogenic bacteria having resistance to conventional antibiotics. CONSTITUTION: Methylidene piperidinyl oxazolidinone derivatives represented by the formula(1) or pharmaceutically acceptable salts thereof are provided, wherein X is oxygen or sulfur atom; R1 and R2 are independently hydrogen, cyano, alkyl, halogen, acetoxy, ethoxycarbonyl, hydroxy, hydroxyamino, methoxyimino, aminoethyl, or one or more hetero atom selected from oxygen, nitrogen and sulfur; and n is 1 or 2. The method for preparing the methylidene piperidinyl oxazolidinone derivatives of the formula(1) comprises reacting a compound of the formula(2) with a compound of the formula(3) in the presence of catalyst with or without organic solvent.