发明名称 |
MEDIA MILLING PROCESS FOR THE MANUFACTURE OF ACTIVE PHARMACEUTICAL INGREDIENTS IN PROPELLANTS |
摘要 |
The invention disclosed herein is a novel media milling process performed in an atmosphere of propellants(s) utilizing a resonant acoustic mixing (RAM) device. The process is utilized to reduce the particle size of API (optionally including excipients) to a respirable size range while ensuring the retention of the crystallinity of the milled API. |
申请公布号 |
US2016317391(A1) |
申请公布日期 |
2016.11.03 |
申请号 |
US201415104693 |
申请日期 |
2014.12.12 |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
BHARATWAJ BALAJI;CHAMARTHY SAI PRASANTH;OREKIE CHINEDU G.;SON YOEN-JU |
分类号 |
A61J3/02;A61K31/40;B02C17/20;A61K9/14 |
主分类号 |
A61J3/02 |
代理机构 |
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代理人 |
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主权项 |
1. A milling process comprising (A) adding an API, in the presence or absence of excipients and/or additives, and beads to a container; (B) sealing the container and filling with propellant media; and (C) mixing the container with an acoustic mixing device. |
地址 |
Rahway NJ US |