| 摘要 |
An isolated protein construct comprises a polyepitope derived from multiple human cytomegalovirus protein antigen epitopes conjugated to an extracellular domain of glycoprotein B, which isolated protein is capable of eliciting a cytotoxic T 5 lymphocyte immune response as well as a neutralizing antibody response to human cytomegalovirus. Also provided are pharmaceutical compositions comprising the isolated protein or an adenoviral expression construct for delivery and expression of a nucleic acid encoding the isolated protein for prophylactic and/or therapeutic treatment of human cytomegalovirus infection, particularly in humans. 14 I P4H P4 CLV) 1~4i-1 c oo 0 C,) 0 >I Dhus~Of > Cy ca r34 a.( rN Cy p H0C -0 E-.C P, , H 0.o H *0 w. 1 0 . |
