| 摘要 |
<p>1445668 Resolution of D,L-penicillamine DEUTSCHE GOLD - UND SILBER - SCHEIDEANSTALT 25 Nov 1974 [17 Dec 1973] 50861/74 Heading C2C A process for the optical resolution of D,L- penicillamine comprises transforming the D,L- penicillamine into a thiazolidine-4-carboxylic acid of the general formula wherein: R<SP>1</SP> and R<SP>2</SP> which may be the same or different, represent a hydrogen atom, an alkyl radical with 1 to 8 carbon atoms, or taken together with the carbon atom to which they are attached, R<SP>1</SP> and R<SP>2</SP> may form a ring with 4 to 10 carbon atoms, and Ac represents an acyl group; and reacting the carboxylic acid with an optical isomer of threo-1- (p-nitrophenyl)-2- amino-propane-1,3-diol and recovering one or both of the optical isomers of penicillamine from the salts formed.</p> |
