发明名称 |
α-conotoxin peptide, pharmaceutical composition and use thereof |
摘要 |
The present invention provides a novel α-conotoxin peptide, pharmaceutical composition and use thereof. The present invention further provides a propeptide of the conotoxin peptide, a nucleic acid construct, expression vector and transformed cell of the conotoxin peptide as well as a fused protein of the conotoxin peptide. The present invention discloses a method for blocking acetylcholine receptors as well as a use of the conotoxin peptide in the manufacture of a medicament. The α-conotoxin peptide of the present invention can specifically block acetylcholine receptor (nAChRs, such as α3β2 nAChRs, α6/α3β2β3 nAChR or α3β4 nAChR or α6/α3β4 nAChR), has activity for treatment of neuralgia, addiction, Parkinson's disease, dementia, schizophrenia, cancers, and can be used in the manufacture of a medicament for analgesia and smoking cessation and drug-withdrawal, a medicament for treatment of mental diseases and cancers, as well as a tool drug for neurosciences. |
申请公布号 |
US9469674(B2) |
申请公布日期 |
2016.10.18 |
申请号 |
US201314419584 |
申请日期 |
2013.06.18 |
申请人 |
HAINAN UNIVERSITY |
发明人 |
Luo Sulan;Zhangsun Dongting;Wu Yong;Zhu Xiaopeng;Hu Yuanyan;Bing Hui;McIntosh J. Michael |
分类号 |
A61K38/10;C07K7/00;C07K1/00;C07K14/435;G01N33/94;C07K1/06;C07K1/16;C07K1/30;G01N33/50;A61K38/00 |
主分类号 |
A61K38/10 |
代理机构 |
Scully Scott Murphy & Presser |
代理人 |
Scully Scott Murphy & Presser |
主权项 |
1. A polypeptide, which comprises an amino acid sequence selected from the group consisting of SEQ ID NO: 11 and SEQ ID NO: 12, wherein the carboxyl terminal of the polypeptide is amidated. |
地址 |
Haikou Hainan CN |