AMIDE DERIVATIVES OF VLB, LEUROSIDINE, LEUROCRISTINE AND RELATED DIMERIC ALKALOIDS

摘要

A dimeric indole-dihydroindolecarboxamide of the formula in which the substituents are defined in Claim 1, is prepared. This compound is obtained by reacting a corresponding dimeric indole-dihydroindolecarboxazide with an amine in order to introduce the group -NR<4>R<5>. The resulting product is isolated as a free amine or as a pharmaceutically tolerated salt. The resulting compounds can be used as antineoplastic active compounds.