Method and a system for optimizing a radiation treatment plan based on a reference dose distribution

摘要

A computer-based method for generating an improved radiation therapy treatment plan for a treatment volume having a target and an organ-at-risk. The method includes a step of accessing an existing radiation therapy treatment plan from a memory of a computer, a dose distribution of the existing radiation therapy treatment plan serving as a reference dose distribution; and performing machine parameter optimization on the existing radiation therapy treatment plan with the computer by pursuing an optimization goal to minimize doses to the organ-at-risk, thereby generating the improved radiation therapy treatment plan.

主权项

1. A computer-based method for generating an improved radiation therapy treatment plan used for a radiation therapy apparatus for a treatment volume of a body having a target and an organ-at-risk, the method comprising:
accessing an existing radiation therapy treatment plan for the treatment volume from a memory of a computer, a dose distribution of the existing radiation therapy treatment plan serving as a reference dose distribution, the existing radiation therapy treatment plan being previously created for radiation treatment with the radiation therapy apparatus for the treatment volume of the body of a patient having the target area and the organ-at-risk; and performing machine parameter optimization for machine parameters of a radiation therapy apparatus on the existing radiation therapy treatment plan for the treatment volume with the computer and using the dose distribution of the existing radiation therapy treatment plan as the reference dose distribution, by pursuing an optimization goal to minimize doses to volume units of the organ-at-risk by simulating variation of the machine parameters of the radiation therapy apparatus and calculating a direct relationship between the variation of the machine parameters and a variation of the doses to the volume units, thereby generating the improved radiation therapy treatment plan, wherein at least one optimization function relates the reference dose distribution to a dose distribution of the improved radiation therapy treatment plan throughout the machine parameter optimization, wherein the radiation therapy apparatus delivers radiation according to the improved radiation therapy treatment plan.